Schizophrenia: Biochemical Factors

HideShow resource information
  • Created by: Olivia
  • Created on: 06-03-13 21:46
View mindmap
  • Schizophrenia: Biochemical Factors
    • Genetic factors operate through brain mechanisms.
    • Brain is composed of millions of neurons - main anatomical structure of brain
    • Neurotransmitter- chemical messages transmit impulses across synapses between neurons
    • Neurotransmitters implicated in schiz.
    • Dopamine Hypothesis - Schiz. results from excess dopamine activity at certain synaptic sites
      • Could be caused by excess dopamine by presynaptic neurons, excess of dopamine receptors
        • Phenothiazines are effective in alleviating some of the major symptoms of schiz.
        • Clozapine (most clinically effective treatments) once thought to be weak at blocking dopamine receptors
          • FARDE ET AL (1992): Positron tomography scans have shown it occupies dopamin sites to same extent as other neuroleptic drugs
        • Amphetamines can induce symptoms of acute paranoid schiz. in unaffected people + increase severity of symptoms in previously diagnosed people
        • WONG ET AL (1986): Found a two fold increase in the desity of dopamine receptor sites in patients who had never been treated with drugs compared to ones who had + control group
        • L-Dopa (Parkinson disease) acts by increasing dopamine levels. Can produce schiz. symptoms in previously unaffected individuals
      • Phenothiazines do not work for everyone diagnosed - only alleviate postive symptoms
        • However, different types of schiz. which might have underlying causes
      • It is likely that dopamine is implicated in causing schizophrenia, but this an over simplified explanation
  • Phenothiazines do not work for everyone diagnosed - only alleviate postive symptoms
    • However, different types of schiz. which might have underlying causes

Comments

No comments have yet been made

Similar Psychology resources:

See all Psychology resources »See all Schizophrenia resources »