PYREXIA

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  • PYREXIA
    • (Fever)
      • A rise in body's temperature
        • Above 37.2
          • NOT a FAILURE of body regulating temperatures
            • Body temp. is regulated at higher level than normal
            • Nervous systems feedback to Hypothalamus regulates temperature
              • Body's Thermostat
            • PYROGENS
              • a Circulating Protein
                • Agent producing a fever
                  • Can reset hypothalamus thermostat& cause rise in body temp.
              • PYRO- Fire
              • Exogeneous Pyrogens- derived from outside host
              • Endogenous Pyrogens- produced by individual
              • Pathogens, Bacterial toxins& antigen-antibody complexes:
                • May act as pyrogens
                  • OR
                    • Stimulate release of pyrogens by macrophages

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