Primary Immune Response

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  • Primary Immune Response
    • Cell Mediated
      • T lymphocytes mature in thymus gland
        • Detect non-self antigens:
          • Phagocyte presenting processed antigens
          • Body cells with viral antigens
          • Transplanted tissues with non-self antigens
          • Cancer cells with abnormal antigens
          • Receptors on T cells fit exactly onto different antigen shapes
            • Activates rapid cloning of T cells
              • Memory cells
                • More rapid secondary response
              • Stimulates phagocytosis
                • Engulfs and digests pathogens
              • Activates cytotoxic T cells
                • Kills abnormal/Infected body cells
                  • Make perforin that makes holes in the membrane so it becomes freely permeable
              • Stimulates division of B cells
                • Helper T cells bind to the processed antigen and stimulates B cell division
                  • Antigen enters B cell by endocytosis and gets presented on cell surface membrane
                  • Clonal selection of B cells
                    • Plasma Cells
                      • Secrete antibodies into blood plasma
                    • Memory Cells
                      • Secondary immune response
                        • Don't produce antibodies directly when infected second time, rather go through clonal selection again but faster
        • Most effective against viruses
          • Because viruses replicate inside body cells
    • Humoral
      • B lymphocytes mature in bone marrow
        • Antigen enters the blood and a specific antibody fits to it
          • Antigen enters B cell by endocytosis and gets presented on cell surface membrane

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