Primary Immune Response
- Created by: Niamh M
- Created on: 16-05-18 10:50
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- Primary Immune Response
- Cell Mediated
- T lymphocytes mature in thymus gland
- Detect non-self antigens:
- Phagocyte presenting processed antigens
- Body cells with viral antigens
- Transplanted tissues with non-self antigens
- Cancer cells with abnormal antigens
- Receptors on T cells fit exactly onto different antigen shapes
- Activates rapid cloning of T cells
- Memory cells
- More rapid secondary response
- Stimulates phagocytosis
- Engulfs and digests pathogens
- Activates cytotoxic T cells
- Kills abnormal/Infected body cells
- Make perforin that makes holes in the membrane so it becomes freely permeable
- Kills abnormal/Infected body cells
- Stimulates division of B cells
- Helper T cells bind to the processed antigen and stimulates B cell division
- Antigen enters B cell by endocytosis and gets presented on cell surface membrane
- Clonal selection of B cells
- Plasma Cells
- Secrete antibodies into blood plasma
- Memory Cells
- Secondary immune response
- Don't produce antibodies directly when infected second time, rather go through clonal selection again but faster
- Secondary immune response
- Plasma Cells
- Helper T cells bind to the processed antigen and stimulates B cell division
- Memory cells
- Activates rapid cloning of T cells
- Most effective against viruses
- Because viruses replicate inside body cells
- Detect non-self antigens:
- T lymphocytes mature in thymus gland
- Humoral
- B lymphocytes mature in bone marrow
- Antigen enters the blood and a specific antibody fits to it
- Antigen enters B cell by endocytosis and gets presented on cell surface membrane
- Antigen enters the blood and a specific antibody fits to it
- B lymphocytes mature in bone marrow
- Cell Mediated
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