Pharmaceutical powders

  • Created by: SamDavies
  • Created on: 01-04-19 18:42
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  • Pharmaceutical Powders
    • Particle size analysis
      • Equivalent sphere
      • Sedimentation
      • Coulter counter
      • Microscopy
      • Sieving
    • Powder flow
      • Superior powder properties
        • Large particles
        • Spherical
          • Minimise adhesion + cohesion
            • Large particles
            • Low moisture content
        • High density
        • Low moisture content
        • Loose packing
      • Packing
        • Cubic
        • Rhombohedral
      • Hausner ratio
        • H = tapped density/bulk density
        • Poor flow = >1.25
      • Carrs index
        • C=100 - (100/H)
        • Poor flow = >25
      • Angle of repose
        • tan(a) = h/r
        • Poor flow = >45
      • Improve powder flow
        • Size separation
        • Granulation
        • Spray-drying
        • Reduce moisture content
        • Flow promoting excipients
        • Mechanical assistance
    • Sachets
      • May not give a variable or accurate dose
      • Portable, long shelf-life, reduced excipients
      • Consider organoleptic properties
      • Typically filled by volume and crimped on top
      • Ideal parameters
        • Carrs index < 25%
        • Particle settling < 1sec
        • Wall friction < 20 degrees
        • Kawakita >5
    • Dosage forms
      • Bulk oral powders
      • Bulk topical powders
      • Insufflated powders
      • Granules
    • Types of powder
      • Hygroscopic
      • Deliquescent
      • Efflorescent
      • Eutectic mixtures
      • Effervescent

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