Pharmaceutical powders
- Created by: SamDavies
- Created on: 01-04-19 18:42
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- Pharmaceutical Powders
- Particle size analysis
- Equivalent sphere
- Sedimentation
- Coulter counter
- Microscopy
- Sieving
- Powder flow
- Superior powder properties
- Large particles
- Spherical
- Minimise adhesion + cohesion
- Large particles
- Low moisture content
- Minimise adhesion + cohesion
- High density
- Low moisture content
- Loose packing
- Packing
- Cubic
- Rhombohedral
- Hausner ratio
- H = tapped density/bulk density
- Poor flow = >1.25
- Carrs index
- C=100 - (100/H)
- Poor flow = >25
- Angle of repose
- tan(a) = h/r
- Poor flow = >45
- Improve powder flow
- Size separation
- Granulation
- Spray-drying
- Reduce moisture content
- Flow promoting excipients
- Mechanical assistance
- Superior powder properties
- Sachets
- May not give a variable or accurate dose
- Portable, long shelf-life, reduced excipients
- Consider organoleptic properties
- Typically filled by volume and crimped on top
- Ideal parameters
- Carrs index < 25%
- Particle settling < 1sec
- Wall friction < 20 degrees
- Kawakita >5
- Dosage forms
- Bulk oral powders
- Bulk topical powders
- Insufflated powders
- Granules
- Types of powder
- Hygroscopic
- Deliquescent
- Efflorescent
- Eutectic mixtures
- Effervescent
- Particle size analysis
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