PAX6

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  • PAX6
    • Conserved across a wide range of species
      • All three genes (ey, Sey, PAX6) are homologs - descended from common ancestral gene
    • Known crystal structures of two DNA-binding domains of PAX6
    • Lots of interesting mutations affecting eye development
    • Homeologs
      • Drosophila: ey (eyeless)
      • Mouse: Sey (small eye)
      • Human: PAX6
    • Genetic conditions
      • Aniridia - no iris
    • Domain structure
      • contains pax domain and homeobox domain, both bind specific DNA sequences

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