PAX6
- Created by: kpritchard16
- Created on: 23-12-18 21:44
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- PAX6
- Conserved across a wide range of species
- All three genes (ey, Sey, PAX6) are homologs - descended from common ancestral gene
- Known crystal structures of two DNA-binding domains of PAX6
- Lots of interesting mutations affecting eye development
- Homeologs
- Drosophila: ey (eyeless)
- Mouse: Sey (small eye)
- Human: PAX6
- Genetic conditions
- Aniridia - no iris
- Domain structure
- contains pax domain and homeobox domain, both bind specific DNA sequences
- Conserved across a wide range of species
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