Negative feedback mechanisms for glucose concentration

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  • Normal blood glucose concentration
    • Pancreas detects low blood glucose concentration
      • Alpha cells secrete GLUCAGON and beta cells stop releasing insulin
        • Glucagon binds to receptors on liver cells
          • -Glycogenolysis is activated
            • -Gluconeogenesis is activated
            • - Cells respire less glucose
            • Cells release glucose into the blood
              • Normal blood glucose concentration
                • Pancreas detects low blood glucose concentration
                  • Alpha cells secrete GLUCAGON and beta cells stop releasing insulin
                    • Glucagon binds to receptors on liver cells
                      • -Glycogenolysis is activated
                        • -Gluconeogenesis is activated
                        • - Cells respire less glucose
                        • Cells release glucose into the blood
                  • Pancreas detects blood glucose concentration is too high
                    • BETA cells secrete insulin and alpha cells stop secreting glucagon
                      • Insulin binds to receptors on liver and muscle cells
                        • cells take up more glucose
                          • Less glucose in the blood
                        • Glycogenesis is activated
                          • Less glucose in the blood
                        • Cells respire more glucose
        • Pancreas detects blood glucose concentration is too high
          • BETA cells secrete insulin and alpha cells stop secreting glucagon
            • Insulin binds to receptors on liver and muscle cells
              • cells take up more glucose
                • Glycogenesis is activated
                  • Cells respire more glucose

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