Non-specific respose to infection

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  • Created by: Eva
  • Created on: 10-01-13 13:42
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  • Non-specific response to infection
    • Recognises the difference between self and non-self
      • Reacts against anything non-self
    • Inflammation
      • Locaised infection
      • The damaged cells release histamines
        • Cause blood vessels to dialate causing heat and redness
          • Higher temp reduces effectiveness of pathogen reproduction
        • Cause walls of capillaries to seperate so fluid leaks in
          • Plasma, WBCs and antibodies go to area
      • RASH: wide spread form of inflammation due to tissue damage
    • Fever
      • Hypothelamus maintains body temp
      • Raised body temp reduces pathogen growth and reproductions
      • Specific response more effective at higher temps
      • Negative: above 40oC can lead to denaturation - tissue damage. Loss of water & electrolytes - dehydration
    • Phagocytosis
      • Granulocytes and Agranulocytes engulf and digest pathogens or non-self material
        • Neutrophils (mainly G)
          • Pus: build up of dead neutrophils
        • Macrophages (mainly A)
          • Produce antibodies
      • Inflammation
        • Locaised infection
        • The damaged cells release histamines
          • Cause blood vessels to dialate causing heat and redness
            • Higher temp reduces effectiveness of pathogen reproduction
          • Cause walls of capillaries to seperate so fluid leaks in
            • Plasma, WBCs and antibodies go to area
        • RASH: wide spread form of inflammation due to tissue damage
    • Lyzosyme: destroys cell walls in bodily fluids
    • Interferons
      • Produced when as cell is invaded by a virus
      • Viral-replication-inhibitary proteins
      • Diffuses into other cells and binds to receptors on surface memberanes
      • Helps prevent viral reproduction in cells to limit infection of more cells

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