Neuroscience - Nervous System

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  • Neuroscience : NS & Brain
    • Central Nervous System: control & regulation of physiological processes
      • CNS: The brain and the spinal cord
    • Peripheral Nervous System: Cranial Nerves (attached to the brain) and spinal nerves (throughout the body)
      • CNS communicates with the body through the nerves of the PNS
        • Central Nervous System: control & regulation of physiological processes
          • CNS: The brain and the spinal cord
      • Nerves carry incoming and outgoing information to/from sense organs, glands and muscles.
        • The brain sends signals through the nerves to the muscles (causing behaviour) and the glands (producing internal  physiological processes)
    • Modularity: there are functionally specialized regions in the brain that are domain specific for different cognitive processes
    • The human brain has three main parts: Brain stem, cerebellum & cerebral hemisphere.
    • Neurons
      • Myelination
      • action potential
    • Neurotransmitters
      • Dopamine, Serotonin & noradrenaline
    • Synapses: the conjuction of a terminal button of one neurone and the membrane of the next cell
      • The terminal button belongs to the presynaptic neuron (the first neutron that sends the message)
        • The membrane belongs to the postsynaptic neuron (the cell receiving the message)
          • Motor neurone forms synapses with a muscle and controls its contractions. The strength of the contraction controls the strength of the motor reaction.
            • The terminal button belongs to the presynaptic neuron (the first neutron that sends the message)
              • The membrane belongs to the postsynaptic neuron (the cell receiving the message)
                • Motor neurone forms synapses with a muscle and controls its contractions. The strength of the contraction controls the strength of the motor reaction.
                  • Reactions in the postsynaptic neuron are triggered by protein molecules called receptor molecules.
                    • Key in Lock : activates response
            • Reactions in the postsynaptic neuron are triggered by protein molecules called receptor molecules.
              • Key in Lock : activates response
      • Excitatory synapses excite the postsynaptic neurone to increase likelihood of firing the axon.
        • Inhibitory reduce the likelihood of the firing axon.
        • Excitory effect is achieved by a release of transmitter subject into the synaptic cleft between the pre (terminal button) and postsynaptic neurone (membrane)
          • The effect is then terminated via reuptake.
            • Inhibitory reduce the likelihood of the firing axon.
        • Techniques
          • Lesioning using stereotaxic apparatus for things such as Parkinson's (remove or insert wires to neural connections)
          • EEG : Electrical activity of CNS neurone via electrodes - non invasive and realtime.
            • EDR: Electrical activity of the skin eg: sweat glands
            • POOR Spacial (clarity)  Good temporal (time)
          • EMG: Skeletal muscular electrical activity.
            • EEG : Electrical activity of CNS neurone via electrodes - non invasive and realtime.
              • EDR: Electrical activity of the skin eg: sweat glands
              • POOR Spacial (clarity)  Good temporal (time)
          • ECG : Heart rate (contractions)
          • Neuroimagery
            • CT : brain structure image (invasive- using X-ray)
            • MEG: magnetic current of neurone (can localise unlike EEG)
            • PET : INVASIVE measure of blood flow, brain metabolism, glucose - radioactive
            • fMRI: brain activity using magnetic and radio waves
              • Good Spacial (clarity)  POOR temporal (time)
            • TMS: Transcranial motoring of cortical activity across magnetic fields.
        • DRUGS
          • Drugs facilitate / interfere with synaptic activity - stimulate or reuptake the synaptic receptors.
            • Drugs can also block activity entirely eg: botulinum toxin
          • Alchohol, Barbiturates & tranquillizers depress neural activity
            • Sedation
          • Anphetamine and cocaine stimulate the brain by retarding reuptake... opioids duplicate natural opiates, decreasing pain sensitivity and increasing pleasure and euphoria.
            • Hallucinogentic effects may be due to levels of conciousnessand serotonin secretion.

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