HideShow resource information
  • Created by: lw121x
  • Created on: 08-12-15 19:10
View mindmap
  • Neurochemistry
    • within neurones electrical flow across membranes
    • Synaose is chemical!
    • Loewi
      • frog heart beating, nerves hang out. Stimulation = beat faster. If chemicals squirted chemicals of slow into other jar it should slow it down
    • Chemical communication
      • synaptic cleft, precynaptic cell constantly makes vessels, they wait in an axon until released
        • they then go out and bind to receptor site excite or inhibit it
      • PRE VS POST, relative lavel can be pre synaptic to one cell but post synaptic to another
    • What triggers an AP in a neurone?
      • vestricles full of neurotransmitters held in axon teminal
      • Change in concentration levels of calcium causes ventricles to come down neurotransmitters and merge to post synaptic membrane
        • Channels sensitive to certain chemicals, if neurotrans binds to on up.
          • this releases neurochemicals
    • Lock and key
      • each neurotransmitter has a shape, attach to those that compliment
      • once neurotrasnmitters has change in ligand/ transmittergated ion channel this opens. Closes ion channel.
      • can only happen to post synaptic cell
    • Everytime stimulated = chemical
      • not every tiem pos can inhibit the effects of post synaptic cell. If channel negative already further depolarised from excitation threshold = AP less likely
    • summation synapses
      • just one is not enough! to cause AP
      • if you put a lot of AP all releasing neurones you can get a temporal summation, must be close enough to sum up
      • spatial summation: if a + b + c across neurone many diff points they will add up to get AP, causes local AP
    • Inhibition
      • not always pos
      • effect post syn mem further polarises cell
      • moves away threshold
      • make neg
      • input less likely fire
      • if pos enough to exceed neg = still pos AP
    • Drugs
      • agonist help aid neuro function
    • Neurotransmitters
      • 100 types some only work with other neurotrans, have effect inhibition + excitation 'lock + key'
      • The receptor site has a name for each neurotrans it accepts ie. acetecholine> 'cholingenic'
      • Direct- bind other protein men, change in cell effect ion channel + Indirect- directly ion channel, change shape channel, pos neg
    • Transient effect
      • only effect certain amount of time, only as long as in synapse- active processes to empty synapse
        • some inactivated after being dischanrged by 'clean up' enzymes
        • if not reuptake or destroyed
    • DRUGS
      • agonists - enhance neurotrans function GABA SSRI help it have effect,
      • antagonist impede its effect
      • drugs work by block synaptic reuoptake, counteract clkeaning or mimicking action
      • We can affect synthesis in a cell being made, release turnover how long allowed to stay there to effect reuptake
      • ALCHOL
        • GABA normally binds pos + neg choride ions. Alchol bind and keeps channel open for longer more enter. Binds on GABA receptor, alchocol keeps open = neg ions in cell = further inhibition
      • Cannabis more complex
        • indirect effect GABA neurones reduce GABA
        • less inhibition of post synaptic dopamine neurones> more dop released dopminergeric neurone> extra dop = firing cells these linked to reward
    • Brain is protected from many chemicals...
      • 1900s dyes affecta ll organs but brain
      • blood brain barrier keeps things out
      • LDOPA go to brain convert dop


No comments have yet been made

Similar Psychology resources:

See all Psychology resources »See all neurochemistry resources »