Modular enhancers

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  • Modular enhancers
    • Genes can be controlled by different sets of regulators
    • Diagram shows gcm gene in D. melanogaster involved in gliogenesis
      • Different coloured lines = different regions of DNA required for regulation by activation of genes in different cell lines
      • Different enhancers and possibly different activators
      • Different cell types can have different transcription factors
    • TNF-a genes
      • Enhancer binds different factors depending on stimulus
      • 2 enhancer sequences overlap and share some activators
      • TNF protein produced in response to lipopolysaccharide (in presence of bacteria) - causes an increase in Ca2+ concentration

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