Lustman - Non-adherence - Fluoxetine (depression).

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  • Lustman
    • Aim:
      • To assess the EFFICACY of the anti-depressant FLUOXETINE in treating DEPRESSION by measuring GLYCEMIC control.
    • Methodology:
      • Randomised, control DOUBLE-BLIND study.
    • Participants:
      • 60 participants with DIABETES, 26 had TYPE 1 diabetes, 34 had TYPE 2 diabetes.
    • Procedure:
      • Patients RANDOMLY assigned to either FLUOXETINE or PLACEBO group. Study conducted over 8 WEEKS. Patients assessed for depression using PSYCHOMETRIC tests and their ADHERENCE to their medical regimen was measured by measuring their GHb.
    • Findings:
      • Patients using Fluoxetine reported LOWER levels of depression. They also had LOWER levels of GHb, which indicated their IMPROVED adherence.
    • Conclusion:
      • Measuring GHb in patients with diabetes indicates their LEVEL of adherence to prescribed medical regimes.
      • Greater adherence was shown by patients who were LESS depressed.


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