Limb Development

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  • Created by: Ellie0o0o
  • Created on: 16-05-15 13:14
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  • Limb development
    • Limb field
    • Lateral plate tissue
      • Forms limb bud
    • Signals from intermediate mesoderm
      • Lateral plate tissue
        • Forms limb bud
    • Limb bud
      • Apical Ectodermal Ridge at margin
        • Mainains outgrowth by keeping underlying mesenchyme in undifferentiated state
    • Zone of Polarising Activity
      • block of mesoderm
      • posterior junction of young limb bud and body wall
      • Properties of an organiser
    • Signals
      • FGF10
        • Progress zone
          • Induces FGF8
      • FGF8
        • Competent ectoderm
          • Maintains FGF10
      • Shh
        • Zone Polarising Activity
          • Induces BMP2 and FGF4
      • BMP2
        • Zone Polarising Activity
          • Maintains FGF4
          • Morphogen?
      • FGF4
        • Anterior AER
          • Morphogen?
    • AP axis patterning
      • By Hox genes
        • AbdB group
          • Concentric overlapping groups
          • Centred at the ZPA
    • DV Axis Patterning
      • Wnt 7a
        • Required for Shh maintainance
  • Zone Polarising Activity
    • Maintains FGF4
    • Morphogen?

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