Limb Development
- Created by: Ellie0o0o
- Created on: 16-05-15 13:14
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- Limb development
- Limb field
- Lateral plate tissue
- Forms limb bud
- Signals from intermediate mesoderm
- Lateral plate tissue
- Forms limb bud
- Lateral plate tissue
- Limb bud
- Apical Ectodermal Ridge at margin
- Mainains outgrowth by keeping underlying mesenchyme in undifferentiated state
- Apical Ectodermal Ridge at margin
- Zone of Polarising Activity
- block of mesoderm
- posterior junction of young limb bud and body wall
- Properties of an organiser
- Signals
- FGF10
- Progress zone
- Induces FGF8
- Progress zone
- FGF8
- Competent ectoderm
- Maintains FGF10
- Competent ectoderm
- Shh
- Zone Polarising Activity
- Induces BMP2 and FGF4
- Zone Polarising Activity
- BMP2
- Zone Polarising Activity
- Maintains FGF4
- Morphogen?
- Zone Polarising Activity
- FGF4
- Anterior AER
- Morphogen?
- Anterior AER
- FGF10
- AP axis patterning
- By Hox genes
- AbdB group
- Concentric overlapping groups
- Centred at the ZPA
- AbdB group
- By Hox genes
- DV Axis Patterning
- Wnt 7a
- Required for Shh maintainance
- Wnt 7a
- Zone Polarising Activity
- Maintains FGF4
- Morphogen?
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