Krebs Cycle
- Created by: Jelena
- Created on: 23-03-13 21:24
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- Krebs Cycle
- Location: mitochondrial matrix
- Aerobic (doesn't directly use oxygen)
- 8 steps
- Oxaloacetate recycled
- Final count: 8 NAHD, 2 FADH2, 2 ATP, 6CO2
- The point is to make NADH and FADH
- Preparatory Steps
- Purpose : convert pyruvates to acetyl-CoA (2 carbon molecules)
- Pyruvate enter mitochondria
- Pyruvate is oxidized (1 carbon removed = decarboxylation) and H+ given to NAD+ --> becomes NADH
- Coenzyme CoA attaches to pyruvate, creating acetyl CoA
- CO2 molecules is released
- Step 1
- Acetyl CoA = 2 carbon atom
- Acetyl CoA attaches to oxaloacetate (4 carbon sugar) to create citrate (6 carbon sugar)
- Step 2
- Citrate becomes isocitrate (6 carbon sugar)
- Step 3
- Step 4
- ?-ketoglutarate loses H+ to NAD+ = NADH
- CO2 is released
- Coenzyme A molecule is added
- Succinyl CoA (4 carbon sugar) is formed
- Step 5
- CoA binds to succinyl CoA
- GTP is made
- GTP donates phosphate group to ADP to make one ATP
- Succinyl CoA becomes succinate (4 carbon sugar)
- Step 6
- Succinate sends 2 H+ to FAD = FADH2
- Succinate is oxidized, FAD is reduced
- Succinate becomes fumarate (4 carbon sugar)
- Step 7
- H2O added to fumarate = malate (malate)
- Step 8
- Malate reduces NAD+ to make NADH
- This makes oxaloacetate
- Oxaloacetate units with acetyl CoA to start the reaction again
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