Cells and Organelles-Interaction of signal sequences with the ER membrane

  • Created by: jessica
  • Created on: 25-02-13 16:32
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  • Interaction of signal sequences with the ER membrane
    • Signal sequence on emerging polypeptide is exposed
      • Signal recognition particle (SRP) binds to the signal peptide
        • The SRP bound complex binds to the SRP receptor on the ER
          • SRP and receptor dissociate and the signal peptide binds to the translocon and the gate opens
            • The ribosome covers the gate and the protein loops into the translocon
              • The polypeptide chain elongates through the translocon and the signal peptide is cleaved by signal peptidase
                • The polypeptide chain enters the ER lumen and begins to fold
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