Immunology

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  • Immunology
    • Complement
      • Classical: c1q/c1r/c1s/c4/c2
        • C3b: Opsonisation
      • MB Lectin: MBL/MASP/c4/c2
        • C4a/c3a/c5a: Recruitment phagocytosis
      • Alternative: c3/b/d
        • c5b/6/7/8/9: Lysis
    • Gram Negative: LPS
    • Gram Positive: Lipoteichoic Acid
    • Collectins- Serum
    • TLR1/2/6: Peptidoglycan, lipoproteins, lipoarabinomannan (mycobacteria), GPI (T cruzi), Zymosan (yeast)
    • TLR 3: ds RNA
    • TLR 5: Flagellin
    • TLR 4: LPS Gram -
    • TLR-9: Unmethylated CpG DNA
    • NOD1: y-glutamyl diaminopimelic acid (GRAM - PGN) NOD 2: muramyl dipeptide
    • Neutrophil: H2O2+Cl.=OCl. + H2O / OCl.+H2O=O2+Cl.+H2O/2O2-+2H+=H2O2+O2/H2O2= H2O + O2
    • Macrophages: IFNy+TNFa= O2+ Arg= NO + Cit (NO synthetase/tetrahydrobiopterin)
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