Immunity: Specific Defences

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  • Antigen present cell (phagocyte with antigens from pathogen)
    • Activate specific Th cells
      • Pathogens with specific antigens
      • Infected body cells displaying antigens
      • Clonal selection; receptor that is complementary to shape of antigen
        • Clonal expansion; Specific Th then divides by mitosis to make lots of Th cells
          • More phagocytes stimulated to engulf pathogens
          • Make memory Th cells for future infections
          • Specific Tc cells activated
            • Kills infected body cells or abnormal cells e.g. cancer
              • Produces perforin protein to make holes in cell membranes causing death
          • Specific B cells activated
            • (antigen complementary to B cell receptor on cell membrane)
            • Clonal expansion; Divides by mitosis
              • Some become plasma cells
                • Make antibodies to stop infection
              • Some become memory cells
                • Protect against future injections
                • Specific Tc cells activated
                  • Kills infected body cells or abnormal cells e.g. cancer
                    • Produces perforin protein to make holes in cell membranes causing death
  • Cell mediated immunity (Tcells)
  • Hummoral immunity
  • KEY

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