Hypopituitarism

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  • Hypopituitary
    • Etiologies
      • Primary
        • Surgery, Radiation, Tumors (primary or metastatic), infection, infiltration (sarcoid, hemochromatosis), autoimmune, ischemia (including Sheehan's), carotid aneurysms, cavernous sinus thrombosis, trauma
      • Secondary
        • Hypothalamic dysfunction or stalk interruption: tumors (craniopharyngioma), infection, infiltration, radiation, surgery, trauma
    • Clinical
      • Mass
        • headache, visual field changes, cranial nerve palsies, galactorrhea
      • Hormonal
        • ACUTE: Weakness, easy fatigability, hypotension, polyuria and polydipsia  CHRONIC: bradycardia, sexual dysfxn, loss of axillary and pubic hair, weight loss, amenorrhea
      • Apoplexy
        • Sudden headache, N/V, visual field changes, cranial nerve palsies, meningismus, change in mental status, hypoglycemia hypotension
    • Diagnostic Studies
      • Hormonal Studies
        • Decreased ACTH
        • Decreased TSH
        • Decreased PRL
        • Decreased GH
        • Decreased FSH & LH
        • Decreased ADH
      • Pituitary MRI
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