Humoral Immunity
- Created by: Jack
- Created on: 03-05-15 17:00
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- Humoral immunity
- Defence against extracellular microbes
- Fungi, helminths, some bacteria
- Bacteria: Staph. Aur., E.coli, Strep. pneu.
- Protozoa: Trypanosoma brucei
- Helminths: Echinococcus Schistosoma mansoni ascaris lumbricoides wuchereria bancrofti
- Fungi, helminths, some bacteria
- Mediated by Th2 and B cells
- 3 effector responses
- Macrophage suppression
- Macrophage regulation
- IL-10/4
- Macrophage regulation
- Antibody production
- Eosinophil activation
- Macrophage suppression
- CD4+ helper T cells
- TH2 cells following Ag-signal-MHCII-restricted, co-stimulatory signal, cytokines (IL-4) - polarisation
- Antibody isotypes
- IgD - membrane receptor
- IgG - opsonisation, complement activation, passive immunity-placenta, ADCC
- IgA - mucosal, neutralisation
- IgE - helminth, allergy
- IgM - membrane receptor, complement activation, neutralisation, mucosal
- Defence against extracellular microbes
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