Humoral Immunity

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  • Humoral immunity
    • Defence against extracellular microbes
      • Fungi, helminths, some bacteria
        • Bacteria: Staph. Aur., E.coli, Strep. pneu.
        • Protozoa: Trypanosoma brucei
        • Helminths: Echinococcus Schistosoma mansoni ascaris lumbricoides wuchereria bancrofti
    • Mediated by Th2 and B cells
    • 3 effector responses
      • Macrophage suppression
        • Macrophage regulation
          • IL-10/4
      • Antibody production
      • Eosinophil activation
    • CD4+ helper T cells
      • TH2 cells following Ag-signal-MHCII-restricted, co-stimulatory signal, cytokines (IL-4) - polarisation
    • Antibody isotypes
      • IgD - membrane receptor
      • IgG - opsonisation, complement activation, passive immunity-placenta, ADCC
      • IgA - mucosal, neutralisation
      • IgE - helminth, allergy
      • IgM - membrane receptor, complement activation, neutralisation, mucosal

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