Haematopoiesis

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  • Macrophage
    • recognition of pathogen - removal through phagocytes
      • Key stimulus factors: IL-3, GM-CSF, TNF
    • Blood Cell Production and Function
      • Eosinophils
        • Transcription factors: IL-5 and GM-CSF
        • Bilobed nucleus
      • Basophils
        • Non-phagocytic granulocytes
        • Lobed nucleus
        • Granulated cytoplasm
        • Transcription factors: SCF,  G-CSF
      • Mast Cells
        • Two types: muscosal mast cells in the gut & lung, or connective tissue mast cells
        • Mediator in  allergic ans inflammatory conditions
        • Activated cells increase vascular permeability, vasodilation and smooth muscle contraction
        • Found in tissues
  • Granulocytes
    • Leukocytes prominent granules
      • Examples: Neutophils (50-70%) , Eosinophils, Basophils and Mast Cells
    • Blood Cell Production and Function
      • Eosinophils
        • Transcription factors: IL-5 and GM-CSF
        • Bilobed nucleus
      • Basophils
        • Non-phagocytic granulocytes
        • Lobed nucleus
        • Granulated cytoplasm
        • Transcription factors: SCF,  G-CSF
      • Mast Cells
        • Two types: muscosal mast cells in the gut & lung, or connective tissue mast cells
        • Mediator in  allergic ans inflammatory conditions
        • Activated cells increase vascular permeability, vasodilation and smooth muscle contraction
        • Found in tissues
  • Neutophils
    • Multi-lobed nucleus with a granulated cytoplasm
      • primary granules: peroxidase and lysozyme
      • Secondary granules: collagenase, lysozyme
    • Transcription factors: IL-3, IL-6

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