Haematopoiesis
- Created by: ellenrobinson
- Created on: 14-05-19 11:22
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- Macrophage
- recognition of pathogen - removal through phagocytes
- Key stimulus factors: IL-3, GM-CSF, TNF
- Blood Cell Production and Function
- Eosinophils
- Transcription factors: IL-5 and GM-CSF
- Bilobed nucleus
- Basophils
- Non-phagocytic granulocytes
- Lobed nucleus
- Granulated cytoplasm
- Transcription factors: SCF, G-CSF
- Mast Cells
- Two types: muscosal mast cells in the gut & lung, or connective tissue mast cells
- Mediator in allergic ans inflammatory conditions
- Activated cells increase vascular permeability, vasodilation and smooth muscle contraction
- Found in tissues
- Eosinophils
- recognition of pathogen - removal through phagocytes
- Granulocytes
- Leukocytes prominent granules
- Examples: Neutophils (50-70%) , Eosinophils, Basophils and Mast Cells
- Blood Cell Production and Function
- Eosinophils
- Transcription factors: IL-5 and GM-CSF
- Bilobed nucleus
- Basophils
- Non-phagocytic granulocytes
- Lobed nucleus
- Granulated cytoplasm
- Transcription factors: SCF, G-CSF
- Mast Cells
- Two types: muscosal mast cells in the gut & lung, or connective tissue mast cells
- Mediator in allergic ans inflammatory conditions
- Activated cells increase vascular permeability, vasodilation and smooth muscle contraction
- Found in tissues
- Eosinophils
- Leukocytes prominent granules
- Neutophils
- Multi-lobed nucleus with a granulated cytoplasm
- primary granules: peroxidase and lysozyme
- Secondary granules: collagenase, lysozyme
- Transcription factors: IL-3, IL-6
- Multi-lobed nucleus with a granulated cytoplasm
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