Gottesman

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  • Gottesman
    • Aim
      • To investigate the probability (chance) of a child with TWO parents with psychiatric illness being diagnosed with the same disorder as their parents
    • Sample
      • Using the Civil Registration System of Denmark, those aged 10+ before Jan 2007, born during or after 1968, who had clear records of biological parents, were sampled from.
        • 2,685,301 were studied, some with more than one child
    • Method
      • Quasi experiment: individuals who had been admitted to a psychiatric hospital and diagnosed with either depression, bipolar, or schizophrenia were identified from the Psychiatric Central Register. The children of each couple were checked on the Register as well for records of admittance to a Psychiatric hospital and their diagnoses upon discharge. The diagnosis was made using the ICD-8 or ICD-10.
    • Findings
      • When BOTH parents have Bipolar, there's a 24.9% probability of the child having Bipolar, and when ONE parent has the disorder, there's a 4.4% probability of the child having Bipolar, there's a 0.48% probability of the child having Bipolar.
      • When BOTH parents have the disorder, there's a 27.3% probability of the child having Schizophrenia, and when ONE parent has the disorder, there's a 7% probability of the child having Schizophrenia, whereas when NEITHER parent has a disorder, there's a 0.86% probability of the child having Schizophrenia.
      • Children do not always have the same diagnosis as their parents.
    • Conclusions
      • The risk of developing Bipolar is approximately 50x as great when both parents have Bipolar compared to when neither do, and 4x as great when one parent has Bipolar compared to when neither do, indicating this is due to the possibility of inheriting a gene predisposing you to bipolar.
      • The risk of developing Schizophrenia is approximately 30x as great when both parents has it compared to when neither do, and 8x as great when one parent has it compared to when neither do. Indicating this is due to the possibility of inheriting a gene predisposing you to Schizophrenia.
      • This could be expalined by the fact that there mus be an interaction between a genetic vulnerability and an environmental trigger for Schizophrenia or Bipolar to develop.

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