Genetic Factors of Schizophrenia
- Created by: Amber-Jade
- Created on: 26-02-13 17:18
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- Genetic Factors
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- Schizophrenia more common among biological relatives of person with schizophrenia
- Twin Studies - Joseph (2000) pooled data shows nconcordance rate for MZ twins of 40% and DZ twins 7%
- Use of 'blind' diagnoses produces lower concordance rate for MZ twins but still higher than DZ
- Adoption study by Tienari - if biological mother schizophrenic, 6.7% of adoptees also schizophrenic
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- Environments of MZ twins may be more similar than for DZ twins
- Differences in concordance rates may reflect environmental similarity rather than role of genetics
- The fact that schizophrenia runs in families may be due to factors that have nothing to do with heritability
- Adopted children form schizophrenic backgrounds may be adopted by particular adoptive parents, making conclusions difficult to draw
- Many studies have to include 'schizophrenia spectrum disorders' to show genetic influences
- Evolutionary perspective - schizophrenia may have adaptive advantage
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