Genetic Control of Cell Division

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  • Created by: emma
  • Created on: 16-04-13 15:55
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  • Genetic control of cell division
    • Tumour supressor genes
      • Opposite to
        • Proto-oncogenes
          • stimulate cell division
            • Normal cell?
              • growth factors attach to receptor protein on CSM and 'switch on' paticular genes via relay protein in cytoplasm
            • Gene mutation causes proto-oncogenes to mutate into oncogenes?
              • oncogene
                • receptor protein on CSM permenantley activated
                  • cell division is switched on, even in the absence of growth factors.
                    • cells divide too rapidly so tumor/cancer develops
                • code for growth factor that is produced in excessive amounts
                  • excessive cell division
                    • cells divide too rapidly so tumor/cancer develops
      • inhibit cell divison
        • normal tumor supressor gene?
          • maintain normal rates of cell division and prevent tumors
        • mutated tumor supressor gene?
          • inactivated!
            • stops inhibiting cell division
              • cell division increases
                • mutant cells formed - structuarly and functionally different from normal cells
                  • most die
                  • clone selves and form tumors
                  • survivors...
    • Proto-oncogenes
      • stimulate cell division
        • Normal cell?
          • growth factors attach to receptor protein on CSM and 'switch on' paticular genes via relay protein in cytoplasm
        • Gene mutation causes proto-oncogenes to mutate into oncogenes?
          • oncogene
            • receptor protein on CSM permenantley activated
              • cell division is switched on, even in the absence of growth factors.
              • code for growth factor that is produced in excessive amounts
                • excessive cell division

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