Function of the liver continued

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  • Functions of the liver II
    • Detoxification of ALCOHOL:
      • Alcohol is broken down in the HEPATOCYTES by the enzymes ETHANOL DEHYDROGENASE to produce ETHANAL.
        • ETHANAL is DEHYDROGENATED further by ETHANAL DEHYDROGENASE into ETHANOATE.
          • ETHANOTE combines with COENZYME A to produce ACETYL COENZYME A. This enters the KREBS cycle + is metabolised to produce ATP. REDUCED NAD is produced.
    • NAD:
      • NAD required to OXIDE and BREAK DOWN FATTY ACIDS for use in RESPIRATION.
      • If there is too much alcohol, NAD can't break down fatty acids so these starts to BUILD-UP which will DESTROY the liver structure.
      • Fatty acids are converted into back to LIPIDS and STORED in hepatocytes. This ENLARGES the liver which can lead to alcohol related HEPATITIS or CIRRHOSIS.
    • CIRRHOSIS:
      • DAMAGED hepaatocytes are replaced by FIBROUS TISSUE. Structure of blood supply is LOST.
      • This causes an INCREASE in AMMONIA CONCENTRATION which can cause major DAMAGE to the CENTRAL NERVOUS SYSTEM.

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