Functions of the Liver

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  • Functions of the Liver
    • Synthesis
      • Plasma Proteins
        • Albumin
        • Fibrinogen
        • Prothrombin
      • Bile
        • Emulsifies fat
        • Neutralises stomach acid
      • Cholestrol
      • Erythrocytes (foetus)
        • Made in the bone marrow after birth
    • Control
      • Blood Glucose
      • Lipids
        • Concentrations
        • Amounts
      • Amino Acids
        • Transamination- changes the R group.One amino acid is changed to another
        • Excess AA's need to be excreted
          • Deamination
          • AA +O2 ----> Keto Acid +Ammonia
        • Ornithine  Cycle
    • Storage
      • Glycogen
      • Iron
      • Vitamins
        • D
        • A
        • B12
    • Breakdown
      • Erythrocytes
        • By Kupffer cells in sinusoids
          • Produces Billirubin (brown pigment)
            • Excreted in bile &faeces
        • Hormones
          • Testosterone
          • Oestrogen
          • Removes Insulin
          • Thyroxine
    • Detoxification
      • Hydrogen Peroxide
        • Converts Hydrogen peroxide to water and oxygen
        • H2O2------>H2O+ 1/2 O2
        • Liver contains catalase
      • Drugs
        • Barbiturates
        • Antibiotics
        • Paracetomol
        • Can be: Oxidised , Reduced , Methylated or combined with another molecule
      • Alcohol (Ethanol)
        • Ethanal
          • Ethanoic Acid
            • Acetyl Co A
              • Krebs Cycle
          • NAD ----> Reduced NAD
            • NAD is no longer used for oxidising fatty acids
              • Fat deposits in the liver
                • Scarring
                  • Cirrhosis
        • NAD ----> Reduced NAD

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