Fat Synthesis
- Created by: ctlnclrk
- Created on: 22-02-19 12:57
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- Lipid Synthesis
- Lipids in the Body
- Lipids come from
- Diet (absorbed)
- FFAs
- Monoacylglycerides
- Cholesterol
- Conversion of dietary FAs into required FAs
- Elongation
- Desaturation
- Conversion of excess
- Carbohydrates
- Protein
- Diet (absorbed)
- Turned into
- Triglycerides
- 90%
- Diglycerides
- Phospholipids
- Glycolipids
- Triglycerides
- Lipids we absorb form lipids in the body
- TGs in food
- Consumed
- Digested
- TG's in body may be different from those in diet
- Absorbed
- De novo synthesis
- Forming TGs
- Using
- Glycerol
- FFAs
- From diet
- Fatty acid composition in body determined primarily by FA composition indiet
- Synthesis of different TGs
- Using same FAs
- TGs in food
- Lipids come from
- Synthesis of Triglycerides
- Structure
- Three fatty acids
- Generic Structure: CH3-(CH2)n-CH2-CH2-COOH
- Attached to glycerol
- Ester linkages
- Neutral fats
- Neutralises COOH group
- Fatty Acid no longer acidic
- Ester linkages
- Three fatty acids
- Location
- Liver
- Adipose
- Getting Glycerol
- Liver
- Dietary TG
- Mobilisation of adipose TGs
- Liver and Adipose
- Dietary glucose
- Needs phosphorylated
- Form ester link
- To Glycerol Phosphate
- Availability
- Any glycerol from
- FFA release
- Mobilisation of adipose
- Needs transported to the liver
- Phosphorylated
- Into glyceryl-3-Phosphate
- Can
- Enter gluconeogenesis
- Be oxidised
- Used to synthesis new TGs
- Can
- Glycerol Kinase
- Uses ATP
- Into glyceryl-3-Phosphate
- Phosphorylated
- Any glycerol from
- Liver
- Glycerol 3 Phosphate
- from Dietary Glucose
- Location
- Liver
- Adipose
- Glycolysis
- DHAP produced
- Intermediate compound
- Usually continues oxidation
- Glycolysis = energy needed
- Energy need satisfied
- Excess produced
- Shunted off for G-3-P synthesis
- Insulin regulated
- Only occurs in fed state
- Glycerol Phosphate DHA
- Enzyme
- NADH --> NAD+
- Glycerol 3 Phosphate
- DHAP produced
- Location
- from Dietary Glucose
- Process
- Phosphorylation of glycerol
- Prepares for esterification
- Form TG
- Free Fatty Acids
- Acylated
- Prepared for esterification
- Turned to Fatty Acyl CoA
- Addition of acyl group
- Acylated
- Step 1
- Fatty Acyl CoA Added
- Carbon 1
- Forms Lysophosphotadic Acid
- Step 2
- Fatty Acyl CoA added
- Carbon 2
- Phosphatidic Acid
- Step 3
- Phophate group removed
- Carbon 3
- Diacylglycerol formed
- Step 4
- Fatty Acyl CoA added
- Carbon 3
- Triacyl glycerol
- Enzymes
- Steps 1,2,4
- Acyltransferase
- Step 3
- Phosphatase
- Steps 1,2,4
- Phosphorylation of glycerol
- Fate
- Adipose tissue
- Stored
- Liver
- Transported
- Mechanism for delivering specific FAs to different tissues
- Around body
- Via VLDL
- Very low density lipoproteins
- Transported
- Adipose tissue
- Structure
- Lipids in the Body
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