RNA Polymerase II Promoter
- Created by: Ellie0o0o
- Created on: 28-04-15 09:04
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- Eukaryotic Pol II Promoters
- Core Promoter
- Proximal to, sometimes overlapping the start of the transcription site
- Cis-acting
- Sufficient for basal levels of transcription in vivo
- Start site
- Always +1
- Usually flanked by Cs and Ts
- TATA Box
- Equivalent to the -10 sequence in bacteria
- ~ 25-30 bps upstream
- AT rich
- Flanked by Cs and Gs
- Initial target site for assembly of polymerase for basal transcription
- Initiators are sometimes also present
- Can have initiators or TATA box, both or neither
- Initiators are sometimes also present
- Can have initiators or TATA box, both or neither
- Regulatory Region
- Usually distal
- Can be in-trans
- Alters transcription from basal level
- Modular
- Core Promoter
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