Coagulation cascade
- Created by: MazzaW
- Created on: 06-12-19 12:16
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- Damaged blood vessel
- Exposed tissue factor (attached to endothelium)
- Binds to and activates factor VII
- Activates factor X
- Activates thrombin from prothrombin
- Converts fibrinogen to fibrin monomer
- Forms fibrin polymer
- Activates intrinsic pathway (factors VIII, IX, XI and XII)
- Amplifies and propagates signals
- THROMBIN BURST
- Activates thrombin from prothrombin
- Converts fibrinogen to fibrin monomer
- Forms fibrin polymer
- Activates intrinsic pathway (factors VIII, IX, XI and XII)
- Amplifies and propagates signals
- THROMBIN BURST
- THROMBIN BURST
- Assessed by APTT
- Vitamin K dependent
- Amplifies and propagates signals
- Converts fibrinogen to fibrin monomer
- Activates thrombin from prothrombin
- THROMBIN BURST
- Assessed by APTT
- Vitamin K dependent
- Amplifies and propagates signals
- Converts fibrinogen to fibrin monomer
- Final common pathway
- Also involves factor II
- Vitamin K dependent
- Activates factor X
- Final common pathway
- Also involves factor II
- Vitamin K dependent
- Vitamin K dependent
- Also involves factor II
- Final common pathway
- Activates factor X
- Vitamin K dependent
- Also involves factor II
- Activates thrombin from prothrombin
- Assessed by PT
- Extrinsic pathway
- Vitamin K dependent
- Activates factor X
- Binds to and activates factor VII
- Exposed tissue factor (attached to endothelium)
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