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  • Created by: Jessica
  • Created on: 13-12-12 23:20
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  • Cholera
    • "Vibrio cholerae"
      • Prokaryotic cell
        • No true nucleus: - has a large circle of DNA
        • No membrane bound organelles
        • Smaller ribosomes (70s type)
        • Cell wall made of polypeptides and polysaccharides
        • Cytoplasm - Jelly like containing enzymes and other soluble materials
        • Capsule covered in a mucilaginous layer of slime.
    • How it causes disease
      • Most of the bacteria is killed by the acidic conditions of the stomach but a few many survive f the pH is above 4.5
      • Use their flagellum to propel themselves through the intestinal wall
      • Produce a toxin protein which has 2 parts to it
        • The other enters the epithelial cells
          • causes ion channels to open causing the chloride ions to flood into the lumen of the S.Intestine
          • Raises W.potential in epithelial cells but lowers W.potential in the lumen
            • this causes water to flow from the cells to the lumen
        • One binds to the receptors of the cell surface membrane
    • Transmission
      • water not properly purified
      • untreated sewage leaks
      • food contaminated by people who prepare and serve it
      • organisms *such as shellfish) which have fed on untreated sewage released into rivers or sea


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