- Carlsson et al
- To present the current view of the relationship between schizophrenia and dopamine dysfunction
- Carlsson did not carry out his own research
- PET is a brain imaging technique which injects the participant with a radioactive tracer that dissolves in the blood stream.
- Some PET tracers are designed to bind to receptors on neurons in the brain. They wont be able to do this if the neurotransmitters are over-active
- They wanted to review the methods and findings of studies looking into dopamine and schizophrenia
- There is no sample
- There is no IV
- There is no DV
- It is unlikely that dopamine is the only dysfunctional neurotransmitter in schizophrenia
- Dopamine change may come from some other changes in people.
- Noradrenaline, serotonin, acetylcholine, glutamate and GABA relate to schizophrenia
- There might be sub populations of those with schizophrenia and there might be different causes within the subpopulation
- Glutamate deficiency leads to more positive symptoms in schizophrenia
- Strengths and weaknesses
- Strength - Sendt et al's review confirms carlssons suspicions of glutamate. Drugs focusing on dopamine do not work.
- Weakness- Due to Carlsson looking into experiments with animals there is a lack of validity relating it to humans
- Research is time locked due to it being done so long ago. It may no longer be representative
- The research is reliable and it follows a standardised procedure
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