Neuranatomical Explanation of Schizophrenia
- Created by: Lisgoe
- Created on: 04-11-14 21:10
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- Neuroanatomy
- Increasing evidence that people with Sz may have structural abnormalities of the brain
- Frontal Lobe Abnormalities
- Area responsible for higher intellectual functioning and fluent language
- Frontal lobes of Sz's have found to be smaller, compared to non Sz's
- Buchsbaum
- PET scans showed reduced blood flow in frontal lobes
- Those diagnosed with Sz
- PET scans showed reduced blood flow in frontal lobes
- Szesko
- Found asymmetry in normal brains is absent is Sz's
- Prefrontal Cortex
- Found asymmetry in normal brains is absent is Sz's
- Ventricle Abnormalities
- Cavities in the brain
- Filled with cerebrospinal fluid
- Anderson et al (1990)
- Controlled CT study
- Found a significant enlargement in ventricles of Sz patients
- Compared to controls
- Only the case for males
- Suggests testosterone may have an affect on the physical presentation of Sz
- Found a significant enlargement in ventricles of Sz patients
- Controlled CT study
- Cavities in the brain
- Limbic System Abnormalitles
- Jernigan et al (1991)
- Found that Schizophrenic patients have abnormalities in the limbic system
- Jernigan et al (1991)
- Limitations
- The abnormalities are not all present in people with Sz
- Suggests there are 2 types of Sz
- Each has a different underlying pathology
- Crow (1985)
- Type 1
- Genetically inherited disorder
- Associated with dopamine dysfunction
- Characterised by positive symptoms
- Acute onset
- Good inter-episodic functioning
- Responds well to antipsychotics
- Type 2
- Neuro- developmental disorder
- Arising from:
- Prenatal insults
- Effects the baby in the womb
- Perinatal insults
- Occurs around time of birth
- Obstetric complications
- Occurs around time of birth
- Prenatal insults
- Type 1
- "Two syndrome hypothesis" accounts for contradictions seen in findings of studies
- Simplistic
- Many diagnosis cases of Sz show both types
- Acute Sz often develops into a more chronic form
- Many diagnosis cases of Sz show both types
- Suggests there are 2 types of Sz
- The abnormalities are not all present in people with Sz
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