Biological Therapies to Schizophrenia

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  • Created by: The Shrew
  • Created on: 26-04-15 15:20
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  • Biological Therapies
    • Drug Therapy/ Chemo-therapy
      • Conventional or neuroleptic drugs
        • Reduce symptoms by blocking dopamine
        • Produce symptoms of neurological diseases
        • Thorazine
        • Prolexin
        • Haldol
      • Comer
        • Reduce Positive symptoms
          • More effective than any other treatment used alone
      • Birchwood and Jackson
        • No convincing evidence for effect on negative symptoms
      • Sampath et al
        • Ps taken drugs for 5 years
          • One group continues with drug
            • Relapse- 33%
          • One group given placebo
            • Relapse- 75%
        • Ross and Read
          • P goes through withdrawal
            • Previously blocked receptor site flooded with neuro-transmitter
      • Bailey et al
        • 30% patients intolerant or unresponsive to drug
      • Wingassen
        • 50% suffer grogginess or sedation
        • 18%- concentration problems
        • 16%- blurred vision
      • Neuroleptic Malignant Syndrome
        • 2% fatal
        • Fever
        • Altered conciousness
        • Muscle rigidity
      • Symptoms of Parkinson's Disease
      • Tardive Dyskinesia
        • 20% of patients using for over 1 year
        • 27% after 7 years
        • Involuntary sucking
        • Chewing
        • Jerky limb movements
        • Writhing movements of the mouth and face
        • 50% patients quit after less than a year!
    • ECT
      • Small electric currents
        • Right hemisphere to reduce memory loss
      • Strong muscle relaxants and anaesthetic
      • Tharyan and Adams
        • Meta-analysis
          • Short-term benefits smaller than those yielded by drug therapy
          • Unclear for long-term
          • Summary Effect
          • No consistencies across  studies
          • Only significant results published
          • Mathematically sound
      • Braya and Pretrides
        • 42 papers
          • Combinations of ECT with anti psychotics= most effective
      • Campatta
        • Reduction in positive symptoms in patients resistant to drugs
      • Don't know why it works

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