Biological Therapies to Schizophrenia
- Created by: The Shrew
- Created on: 26-04-15 15:20
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- Biological Therapies
- Drug Therapy/ Chemo-therapy
- Conventional or neuroleptic drugs
- Reduce symptoms by blocking dopamine
- Produce symptoms of neurological diseases
- Thorazine
- Prolexin
- Haldol
- Comer
- Reduce Positive symptoms
- More effective than any other treatment used alone
- Reduce Positive symptoms
- Birchwood and Jackson
- No convincing evidence for effect on negative symptoms
- Sampath et al
- Ps taken drugs for 5 years
- One group continues with drug
- Relapse- 33%
- One group given placebo
- Relapse- 75%
- One group continues with drug
- Ross and Read
- P goes through withdrawal
- Previously blocked receptor site flooded with neuro-transmitter
- P goes through withdrawal
- Ps taken drugs for 5 years
- Bailey et al
- 30% patients intolerant or unresponsive to drug
- Wingassen
- 50% suffer grogginess or sedation
- 18%- concentration problems
- 16%- blurred vision
- Neuroleptic Malignant Syndrome
- 2% fatal
- Fever
- Altered conciousness
- Muscle rigidity
- Symptoms of Parkinson's Disease
- Tardive Dyskinesia
- 20% of patients using for over 1 year
- 27% after 7 years
- Involuntary sucking
- Chewing
- Jerky limb movements
- Writhing movements of the mouth and face
- 50% patients quit after less than a year!
- Conventional or neuroleptic drugs
- ECT
- Small electric currents
- Right hemisphere to reduce memory loss
- Strong muscle relaxants and anaesthetic
- Tharyan and Adams
- Meta-analysis
- Short-term benefits smaller than those yielded by drug therapy
- Unclear for long-term
- Summary Effect
- No consistencies across studies
- Only significant results published
- Mathematically sound
- Meta-analysis
- Braya and Pretrides
- 42 papers
- Combinations of ECT with anti psychotics= most effective
- 42 papers
- Campatta
- Reduction in positive symptoms in patients resistant to drugs
- Don't know why it works
- Small electric currents
- Drug Therapy/ Chemo-therapy
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