Biological therapies for schizophrenia

First and second generation antipsychotics 

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  • Biological therapies for sch - drug therapy!
    • Antipsychotic- Introduces in the 1950's, Still used today but superseded by second generation antipsychotic
    • First generation antipsychotic - its though that sch produce too much dopamine or have more D2 receptors. These drugs block D2 receptors.
      • Effectiveness - Reduce positive symptoms in 75% of patients but dont reduce any negative symptoms.
        • Effectiveness - before this drug sch lived in hospitals. The drug has allowed them to live in the community with their families.
          • Effectiveness - serious side effects such as apathetic, increased risk of depression, uncontrollable tremors, not a cure only stops symptoms for as long as the drug is being taken..
    • Second generation antipsychotic - Block D2 and serotonin receptors.
      • Effective against negative symptoms and effective for 25% of patients that werent helped by the first generation.
      • Effectiveness - Can cause weight gain of 5 kg or more and can cause sexual dysfunction.
    • Evaluation.
      • Ross & Read 2004 - being prescribed medication reinforces the view that there is something wrong with you
      • FOR - Allows people to live normally and are cost effective.
      • AGAINST - Some people dont improve, suicide remains high and severe side effects.
  • Second generation antipsychotic - Block D2 and serotonin receptors.
    • Effective against negative symptoms and effective for 25% of patients that werent helped by the first generation.
    • Effectiveness - Can cause weight gain of 5 kg or more and can cause sexual dysfunction.

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