Biological Explanations of Schizophrenia
- Created by: The Shrew
- Created on: 25-04-15 15:04
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- Biological Explanations for Sz
- Twin Studies
- Gottesman
- 40 Studies
- Mz- 48%
- Dz- 17%
- Similar if reared apart as reared together
- 40 Studies
- Cardano et al
- Maudsley Twin Register
- Mz- 40%
- Dz- 5.3%
- Maudsley Twin Register
- Joseph
- 6 Studies
- Fraternal twin concordance higher than non-twin brothers and sisters
- Special case
- Fraternal twin concordance higher than non-twin brothers and sisters
- 6 Studies
- Small Sample size
- Marshall
- Concordance rates reduce with greater control
- Davey
- Mz always same sex
- Davis and Phelps
- Mz more likely to have had shared placenta- intrauterine abnormalities
- Gottesman
- Biochemical Dopamine Hypothesis
- Release by pre synaptic neurones
- Excess of dopamine receptors
- Over-sensitivity of dopamine receptors
- Davidson and Neale
- Pheno-thiazines- dopamine inhibitor
- Block at synapse
- Reduces symptoms
- Block at synapse
- Davis
- Farde et al
- Clozapine
- Occupies receptor sites
- Reduces symptoms
- Occupies receptor sites
- Davidson and Neale
- Pheno-thiazines- dopamine inhibitor
- Block at synapse
- Block at synapse
- Davis
- Farde et al
- Clozapine
- Occupies receptor sites
- Occupies receptor sites
- Clozapine
- Anti-psychotics don't affect symptoms for 6 weeks/ block receptors within hours
- Don't work for everyone
- Farde et al
- Pheno-thiazines- dopamine inhibitor
- Clozapine
- Anti-psychotics don't affect symptoms for 6 weeks/ block receptors within hours
- Don't work for everyone
- Farde et al
- Pheno-thiazines- dopamine inhibitor
- Owen et al
- Post mortem evidence
- Greater density of dopamine receptors in caudate neurons
- Concordant with indirect evidence- needle to the spine (Eysenck)
- Greater density of dopamine receptors in caudate neurons
- Post mortem evidence
- Twin Studies
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