Biological Explanations of Schizophrenia

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  • Created by: The Shrew
  • Created on: 25-04-15 15:04
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  • Biological Explanations for Sz
    • Twin Studies
      • Gottesman
        • 40 Studies
          • Mz- 48%
          • Dz- 17%
        • Similar if reared apart as reared together
      • Cardano et al
        • Maudsley Twin Register
          • Mz- 40%
          • Dz- 5.3%
      • Joseph
        • 6 Studies
          • Fraternal twin concordance higher than non-twin brothers and sisters
            • Special case
      • Small Sample size
      • Marshall
        • Concordance rates reduce with greater control
      • Davey
        • Mz always same sex
      • Davis and Phelps
        • Mz more likely to have had shared placenta- intrauterine abnormalities
    • Biochemical Dopamine Hypothesis
      • Release by pre synaptic neurones
      • Excess of dopamine receptors
      • Over-sensitivity of dopamine receptors
      • Davidson and Neale
        • Pheno-thiazines- dopamine inhibitor
          • Block at synapse
            • Reduces symptoms
        • Davis
          • Farde et al
            • Clozapine
              • Occupies receptor sites
                • Reduces symptoms
            • Davidson and Neale
              • Pheno-thiazines- dopamine inhibitor
                • Block at synapse
                • Davis
                  • Farde et al
                    • Clozapine
                      • Occupies receptor sites
                    • Anti-psychotics don't affect symptoms for 6 weeks/ block receptors within hours
                    • Don't work for everyone
              • Anti-psychotics don't affect symptoms for 6 weeks/ block receptors within hours
              • Don't work for everyone
          • Owen et al
            • Post mortem evidence
              • Greater density of dopamine receptors in caudate neurons
                • Concordant with indirect evidence- needle to the spine (Eysenck)

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