Biological Explanations for Schizophrenia

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  • Created by: Jwalker5
  • Created on: 04-02-14 15:37
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  • Biological Explanations
    • Genetics
      • Family Studies
        • Gottesman
          • 2 SZ parents - 46%.           1 SZ Parent - 13%   Siblings w SZ - 9%
      • Twin Studies
        • Joseph
          • MZ - 40.4% DZ - 7.4%
      • Adoption Studies
        • Tienari et al
          • 164 w mothers w. SZ -- 11 had SZ.  197 control wt. SZ - 4 had SZ
      • Inherit genes from our parents
        • 32 pairs of chromosomes from each. Leaving a predisposition to certain disorders
      • SZ Spectrum Disorder sometimes included into diagnosis of SZ
        • Psychological Explanations not included
    • Dopamine Hypothesis
      • Dopamine is a neurontransmitter that guides attention
        • High levels of dopamine linked to SZ
          • Too many D2 receptors collect dopamine too much
      • Anti-psychotics
        • Dopamine Antagonist - reduces stimulation of dopamine and eliminates hallucinations etc.
      • L-Dopa
        • Low levels of dopamine are found in Parkinson's patients.
          • They're given L-Dopa tp raise levels and found they develop SZ symptoms
      • Amphetamine
        • Dopamine Agonist - stimulates dopamine cyaing synapse to flood. Large does cause hallucainations
      • Haracz - found those who showed high dopamine before death had received anti-psychotics
        • PET Scans - neuroimaging - failed to provide evidence that dopamine affects SZ

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