Genetics and schizophrenia

gentics - biological approach

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  • Biological explanation - genetics!
    • Genetics - prevalence of sch is the same over the world (1%). This supports bioloigcal view as there are no environmental influences.
      • Torrey (2002) - except in Croatia and Ireland 4%.
      • Gottesman 1991 - complied 40 studies to show the risks of developing sch with different familial relationships.
    • Twin studies - Gottesman & Shields reviewed the results of 5 twin studies.
      • MZ twins concordance rate 35% - 58%
        • DZ twins 9% - 26%
      • Problems: small sample, not 100% concordance, same environment.
    • Family studies - The risk of sch rises with the degree of genetic relation (Gottesman).
      • Spouse 1%
      • Parents 6%
      • DZ twins 17%
      • MZ twins 48%
      • Kendler et al - 1st degree relatives of sch are 18 more at risk than general pop.
      • Children whose parents are both sch have a 46% concordance rate.
    • Adoption studies (Nature v Nurture) -
      • Tienari - studied 164 adopted children. those whose mothers had sch had 11% and those who did not 2%.
    • Evaluation - environmental triggers?
  • Problems: small sample, not 100% concordance, same environment.

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