Biochemical explanation of sch - bioloigcal
bicohemical - dopamine
- Created by: Molly Byrne
- Created on: 20-12-13 10:49
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- Biochemical explanation - genetics!
- Dopamine hypothesis - sch is caused by excessive dopamine activity.
- Neurons that transmit dopamine fire too often. Lowering dopamine can help to remove sch symptoms.
- Evidence for the dopamine hypothesis - Neuroleptic drugs are given to sch to block D2 receptors.
- More effective on positive than negative symptoms.
- L Dopa, increases dopamine levels and produces sch symptoms.(Davidson et al).
- A02 Parkinsons disease - patents suffering parkinsons are of relevance.
- They have low levels of dopamine. their symptoms is uncontrollable movement of limbs. these are found in sch who are given neuroleptic drugs.
- A02 Post mortems - Falki et al found in autopises that people with sch have more than usual D2 receptors.
- Faulty chemicals or Sch?
- Unsure is faulty chemicals are the cause of sch? or if sch is the cause of faulty chemicals?
- Evaluation: lack of correspondence between taking drugs and signs of clinical effectiveness.
- Not effective at treating negative symptoms.
- PET scans have suggested drugs didnt reduce symptoms with patients diagnosed with sch for over 10 years.
- Possible that social and environmental factors trigger the disorder.
- Dopamine hypothesis - sch is caused by excessive dopamine activity.
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