PSY- BIO TREATMENT SZ

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  • Created by: lw121x
  • Created on: 24-05-15 13:18
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  • Bio Treatments
    • All antipsychotic drugs block out neurotransmitters
    • Conventional  anti psy
      • primarily used to combat the positive symptoms- products of overactive dop system
        • drugs reduce dop so reduce SZ. They bind to dop receptors to stop stimulation = block action
          • By reducing dop = elimination hallucinations etc...
            • primarily used to combat the positive symptoms- products of overactive dop system
              • drugs reduce dop so reduce SZ. They bind to dop receptors to stop stimulation = block action
                • By reducing dop = elimination hallucinations etc...
        • The effectiveness led to dop hyp
        • Revolutionised treatment for psychotic patients, 65% benefit from medication
          • Davis et al reviewed 29 studies compared placebo relapse rates 55% compared to 19%
        • Take several weeks to work
        • Not so effective in treating neg symptoms
          • diff causes ie. large ventricles and loss brain cells
        • If start drug should remain because body adapted
        • Multiple side effects ie tardive dyskinesia (writhering) no longer 1st option
      • Atypical drugs ie. clozapine
        • also act on dop patjhway temp occupy d2 dop receptors and then rapidly dissociate to allow normal dop transmission
          • characteristic that is thought to have lower side effects than conventional ones
        • 1990 effective 85%
        • Better at treating neg symptoms
        • fewer side effects
        • still risk side effects ie 1/2% develop fatal  whit blood cell condition
        • Leucht meta analysis atypical + typical only 'slightly' more effective
      • Appropriateness of anti psychotics
        • 30% taking conventional anti develop TD irreversibly 75% of cases
        • Few side effects of atypical = more stay on drugs
        • Ross + Read prescribed med reinforces 'something is wrong with them' which reduces look at other sources ie life stress
      • 3rd generation
        • 76 drugs in development each one targets specific set of receptors ie. d1 d2
        • every ind diff abnormality and we can't see what that abnormaility is
      • Overall Eval Drug treatment
        • good
          • more effective any other treatment = strong bio cause
          • works quicker psy therapies
          • allows patient live normal lives
          • best along other reduces relapse
        • bad
          • Ethical. should drugs be taken without consent?
          • Researcher bias funded by drug companies
      • ECT
        • restricted certain forms of SZ ie. catatonic/ haven't responded other treatments
        • Catatonic respond ECT = rapid alleviation of symptoms
        • Thyryan + Adams review 26 studies 800 patients. 'Placebo condition'. More people improved real ECT no indication LT benefit
        • When ECT is compared with antipsy drug = improvement mental state
        • Risk: death, memory loss rarely used

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