Anitpsychotic Medication

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  • Antipsychotic Medication
    • AO1
      • Conventional antipsychotic reduce effects of dopamine and reduce symptoms of schizophrenia.
      • Bind to D2 dopamine receptors but do not stimulate them.
      • Atypical antipsychotics only temporarily occupy D2 receptors then dissociate to allow normal dopamine transmission
      • Leads to lower levels of side effects, such as tardive dyskinesia
    • AO2
      • Davis et al - higher relapse rate in patients whose drugs replaced with placebo than those who remained on drug
      • Antipsychotic medication more effective for those living with hostility and criticism
      • Conventional antipsychotics - 30% develop tardive dyskinesia
      • Being prescribed medication creates motivational deficits which  prevents positive action against illness
      • Meta-anaylsis - superiority of atypical over conventional antipsychotic only moderate
      • Atypical antipsychotic - only marginal support for effectiveness with negative symptoms
      • Lower Rates of tardive dyskinesia with atypical
      • Patients more likely to continue with medication if fewer side effects
      • Ross and Read - placebo studies not a fair test because proportion of relapse explained by withdrawal effects
      • Ethical Issues - human rights issue associated with use of antipsychotic medication

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