Anti psychotics and Schizophrenia
- Created by: Lisgoe
- Created on: 05-11-14 20:54
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- Antiphsychotics
- Conventional Drugs (Neuroleptics)
- Revolutionised treatment of disorders
- E.g. Sz and Bi-Polar
- Main focus
- Positive symptoms
- Reduce the amount of Dopamine
- Binding to dopamine receptors
- Blocks some but not all DP
- Binding to dopamine receptors
- Chloropromozine eliminates hallucinations and delusions
- Associated with overactive DP system
- Revolutionised treatment of disorders
- Atypical Drugs
- Helps patients who don't respond to Conventional drugs
- Alleviates positive symptoms
- Claims to help with Negative symptoms
- Social withdrawal and lack of motivation
- Claims to help with Negative symptoms
- Don't act on DP system
- Block serotonin receptors
- No flooding of DP when off drugs
- Less relapse rates
- No flooding of DP when off drugs
- Block serotonin receptors
- Risperidone used in hospitals
- Improve STM
- Useful for Rehab in living independently
- Contribute to learning of social skills
- Side Effects
- DT v/strong
- Produces SE's
- Monitored
- Dosage
- Monitored
- Produces SE's
- Nausea
- Dry mouth
- Drowsiness
- Changes in weight
- Visual disturbances
- Conventional drugs
- Tardive Dyskinesia
- Uncontrollable tics and movements
- Lips
- Mouth
- Hands
- Feet
- Tongue
- Majorly irreversible
- Uncontrollable tics and movements
- Tardive Dyskinesia
- Teste et al (1999)
- Found fewer people developed TD on Atypical drugs
- Such as Clozapine
- Compared to Conventional drugs
- Such as Clozapine
- Found fewer people developed TD on Atypical drugs
- Termination of treatment
- Leads to relapse and hospitalisation
- May switch to Atypical drugs
- DT v/strong
- Effectiveness
- Not all patients are responsive to AP's
- Chronic Sz can't be medicated
- Some studies suggest Atypical drugs to be more effective than Conventional AP's
- Placebo Effect
- Davis et al
- Suggested relapse rates were higher in placebo replaced drugs
- Argued that withdrawal leads to flooding of DP
- Relapse may be linked to withdrawal effects
- Argued that withdrawal leads to flooding of DP
- Suggested relapse rates were higher in placebo replaced drugs
- Davis et al
- Dose given during acute episode will be too high for maintenance
- Can produce SE's
- Crisis Point
- Can produce SE's
- Not all patients are responsive to AP's
- Conventional Drugs (Neuroleptics)
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