Antigen Presenting Cells
- Created by: Martha Brown
- Created on: 16-05-15 03:10
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- Antigen Presenting Cells
- Antigen uptake by Langerhans cells in the skin
- Langerhans cells leave the skin and enter the lymphatic system
- Mature dendritic cells enter the lymph node from infected tissue and can transfer some antigens to resident dendritic cells
- B7-positive dendritic cells stimulate naïve T cells
- Mature dendritic cells enter the lymph node from infected tissue and can transfer some antigens to resident dendritic cells
- Langerhans cells leave the skin and enter the lymphatic system
- Macrophages may not migrate to the lymph nodes
- Immature dendritic cells in peripheral tissues encounter pathogens and are activated by PAMPs
- TLR signaling induces CCR7
- Enhances processing of pathogen-derived antigens
- CCR7 directs migration into lymphoid tissues and augments expression of co-stimulatory molecules (B7) and MHC molecules
- Mature dendritic cell in T-cell zone primes naïve T cells
- Activation of dendritic cells in the lymph node up regulate co-stimulatory molecules such as CD40 and CD86, making them much better at stimulating T cells
- Mature dendritic cell in T-cell zone primes naïve T cells
- CCR7 directs migration into lymphoid tissues and augments expression of co-stimulatory molecules (B7) and MHC molecules
- Enhances processing of pathogen-derived antigens
- TLR signaling induces CCR7
- Antigen uptake by Langerhans cells in the skin
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