Biological Therapies - Antidepressants - DEP

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  • Created by: Tom Kilby
  • Created on: 12-05-13 22:27
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  • Antidepressant
    • Effectiveness critised due to quality of SUPPORT Research
  • The drugs affect availability of serotonin and adrenaline.
    • Antidepressant
      • Effectiveness critised due to quality of SUPPORT Research
  • Monoamne-oxidase inhibitors
    • MO ia a Natrual enzyme - breaks down serotin and noradrenaline.
      • The inhibitors block action of this enzyme - so increase availability of these neurotransmitters in nervous system
        • Monoamne-oxidase inhibitors
          • MO ia a Natrual enzyme - breaks down serotin and noradrenaline.
            • The inhibitors block action of this enzyme - so increase availability of these neurotransmitters in nervous system
            • The drugs affect availability of serotonin and adrenaline.
      • SSRI's
        • E.g. Prozac = most com prescribed
          • SSRI's
          • Work by blocking reuptake of serotonin.
            • Makes more of it available in neighbouring cells = reduce symptoms
              • So more serotonin left in synapse, prolonging it activity.
                • Work by blocking reuptake of serotonin.
                  • Makes more of it available in neighbouring cells = reduce symptoms
                    • So more serotonin left in synapse, prolonging it activity.
            • Effectiveness
              • Giltin =  AD effective reducing sympt of sevERE dep in around 65-75%. Comapared to placebos = 33%
                • Effectiveness
                  • If effective treatment real - then Placebos only used in control group. Unethical to give placebos to DEP patient...
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