Antibiotic Resistance AQA biology AS unit 2
- Created by: Chloe
- Created on: 30-05-13 15:35
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- Antibiotics
- How do they kill?
- Osmotic lysis
- Preventing bacteria forming cell walls. prevents strong crosslinks, weakening walls.
- water entering by osmosis cannot be held in, pressure build up bursts walls, cell dies.
- Preventing bacteria forming cell walls. prevents strong crosslinks, weakening walls.
- Osmotic lysis
- Antibiotic Resistance.
- due to chance mutations making enzyme penicillinase.
- reproduced and wasn't killed by penicillin so spread
- due to chance mutations making enzyme penicillinase.
- How do they kill?
- mutation passed on by conjugation
- Vertical gene transfer
- horizontal gene transfer.
- New resistance mutations occur all the time
- the more we use Antibiotics greater the chance of mutant gaining advantage and replacing normal variety
- TB
- AB's for 6-9 months, many stop taking
- those remaining are most resistant so more resistant form multiplies :(
- AB's for 6-9 months, many stop taking
- those remaining are most resistant so more resistant form multiplies :(
- resistant MRSA
- dangerous b/c
- people in hospitals tend to be sicker, older, weaker so more vulnerable
- many in close proximity, perfect for TRANSMISSION
- dangerous b/c
- lots of AB's used, mutant strains have advantage. So MRSA v difficult to treat.
- many in close proximity, perfect for TRANSMISSION
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