Antibiotic Resistance AQA biology AS unit 2

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  • Created by: Chloe
  • Created on: 30-05-13 15:35
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  • Antibiotics
    • How do they kill?
      • Osmotic lysis
        • Preventing bacteria forming cell walls. prevents strong crosslinks, weakening walls.
          • water entering by osmosis cannot be held in, pressure build up bursts walls, cell dies.
    • Antibiotic Resistance.
      • due to chance mutations making enzyme penicillinase.
        • reproduced and wasn't killed by penicillin so spread
  • mutation passed on by conjugation
    • Vertical gene transfer
    • horizontal gene transfer.
  • New resistance mutations occur all the time
    • the more we use Antibiotics greater the chance of mutant gaining advantage and replacing normal variety
  • TB
    • AB's for 6-9 months, many stop taking
      • those remaining are most resistant so more resistant form multiplies :(
  • those remaining are most resistant so more resistant form multiplies :(
  • resistant MRSA
    • dangerous b/c
      • people in hospitals tend to be sicker, older, weaker so more vulnerable
      • many in close proximity, perfect for TRANSMISSION
  • lots of AB's used, mutant strains have advantage. So MRSA v difficult to treat.
    • many in close proximity, perfect for TRANSMISSION

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