Analgesia
- Created by: rachelvbrown97
- Created on: 27-04-17 20:52
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- Analgesia
- Cell damaged
- Contents spill out (interluekins, cells wall (prostaglandins), hydrogen ions and histamine
- Inflammation response
- Hydrogen ions and histamine have effect on blood vessels in the local area
- Cell walls become further away from each other (blood vessels become more poress).
- This means WBC can pass through into the interstitual fluid where the tissue is to attack the infection.
- This brings an increase in protein and H20 from inside the blood vessel causing oedema.
- This means WBC can pass through into the interstitual fluid where the tissue is to attack the infection.
- Cell walls become further away from each other (blood vessels become more poress).
- Contents spill out (interluekins, cells wall (prostaglandins), hydrogen ions and histamine
- Prostaglandins
- Sensitises the nerve endings. Each sensory nerve has an activation threshold. Prostaglandins lower the activation threshold making it more sensitive to the different chemicals
- Created by Cox-2
- NSAIDS
- Reduce activity of cox-2. Therefore, prostaglandins can no longer have such an effect of sensitising the nerve endings. Activation threshold is not lowered making it more difficult for the chemicals to activate them.Pain is reduced
- NSAIDS have an impact on cox-1 meaning less gastric mucosa is produced leaving the stomach more exposed to the stomach acid which can cause ulceration.
- NSAIDs can also cause blood clotting. If cox-1 and cox-2 are not balanced, clots are formed. Clots can cause: strokes, myocardial infarction and TIAs
- Mouth, stomach (metabolic process begins), gut, portal circulation, liver, systemic circulation, taken to target organs for activation of those receptors.
- Oral=30mg S/C=15 IV=10mg Epidural=1mg Intrathecal=0.1mg
- Untitled
- Oral=30mg S/C=15 IV=10mg Epidural=1mg Intrathecal=0.1mg
- Cell damaged
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