ACP

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  • Acepromazine
    • Antagonist at many receptors
      • Histamine
      • Seratonin
      • Alpha 1
      • Dopamine
      • Choline
    • Phenothiazine
    • Dose dependant side effects
      • Cardio-protection
      • Antiemetic    & anti-spasmodic
      • Extra pyramidal activation
      • Vasodilation
    • Considerations
      • Seizure threshold
      • MDR 1 - mutation
      • Anaemia
      • Sighthounds
      • Splenectomy
      • Brachy-cephalics
      • contraindicated in hypovolamic or dehydrated patients
    • 0.005mg/kg - 0.02mh/kg IV
    • 0.01mg/kg - 0.05mg/kg IM
    • +/- baroceptor reflex
    • Vasodilation
    • Hypotension & Hypothermia
      • Untitled
    • Variable effect
    • Reduces anaesthetic requierments
    • smooth recovery
    • anxiolysis
    • splenic sequestrian
    • noise sensitivity
    • rarely paradoxical effect
    • liver metabolism
    • provide tranquilisation
    • antihistamine activity

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